| Bioactivity | Antiparasitic agent-16, a pyridine-thiazolidinone, has anti-Trypanosoma cruzi and leishmanicidal activities. Antiparasitic agent-16 has IC50s of 1.0 μM and 0.6 μM against trypomastigote and amastigote forms of T. cruzi. Antiparasitic agent-16 has IC50s of 150.2 μM and 16.75 μM against trypomastigote and amastigote forms of L. amazonensis. Antiparasitic agent-16 induces parasite cell death through necrosis induction. Antiparasitic agent-16 induces morphological changes such as shortening, retraction and curvature of the parasite body and leakage of internal content with T. cruzi trypomastigotes[1]. |
| Invitro | Antiparasitic agent-16 (化合物 15) 在 RAW 264.7 中的 CC50 为 47.4 μM[1]。 Antiparasitic agent-16 (1.0, 2.0 μM; 24小时) 促进 T. cruzi trypomastigotes 形式的寄生虫体的形态变化，例如缩短、收缩和弯曲。Antiparasitic agent-15 剂量依赖性地诱导与锥体鞭毛体细胞凋亡相容的显着改变[1]。 Antiparasitic agent-16 (10 μg/mL; 24, 48, 72, 96 小时) 导致受刺激小鼠脾细胞上清液中 IL-10 生成显着减少[1]。 |
| Name | Antiparasitic agent-16 |
| Formula | C18H18N4OS |
| Molar Mass | 338.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Juliana Maria da Conceição, et al. Structural design, synthesis, and anti-Trypanosomatidae profile of new Pyridyl-thiazolidinones. Eur J Med Chem. 2023 Apr 6;254:115310. |
Antiparasitic agent-16
CAS: F: C18H18N4OS W: 338.43
Antiparasitic agent-16, a pyridine-thiazolidinone, has anti-Trypanosoma cruzi and leishmanicidal activities. Antiparasit
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