| Bioactivity | Antioxidant agent-3 (Compound 14q), an potent antioxidant, displays potent DPPH radicals scavenging activity and ABTS+ scavenging activity with IC50s of 26.58 and 30.31 μM, respectively. Antioxidant agent-3 (Compound 14q) increases reactive oxygen species (ROS), superoxide dismutase (SOD) and glutathione (GSH), and reduced lactate dehydrogenase (LDH) in H2O2-treated HepG2 cells[1]. |
| Invitro | Antioxidant agent-3 (Compound 14q) exhibits good activity in DPPH radicals scavenging and ABTS +• scavenging with the values of IC50 is 26.58 μM and 30.31 μM respectively[1].Antioxidant agent-3 shows low cytotoxicity in human normal WI-38 (IC50 > 100 μM) and GES (IC50 > 200 μM) cells[1]. Antioxidant agent-3 can enhance viability of H2O2-induced HepG2 cells[1]. Antioxidant agent-3 decreases the apoptotic percentage of HepG2 cells[1].Antioxidant agent-3 reduces the ROS produce and LDH release, improves GSH and SOD levels in H2O2-treated HepG2 cells, and exhibits more stability in methanol solution[1]. Cell Cytotoxicity Assay[1] Cell Line: |
| Name | Antioxidant agent-3 |
| Formula | C18H14O8 |
| Molar Mass | 358.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wen-Bo Li, et al.Synthesis and antioxidant activity of conjugates of hydroxytyrosol and coumarin. Bioorg Chem. 2020 Dec;105:104427. |