| Bioactivity | Antimycobacterial agent-4 is a 2-amino-4-(2-pyridyl) thiazole derivative, with antimycobacterial activity, antiplasmodial activity, and cytotoxicity on a mammalian cell line[1][2]. |
| Invitro | Antimycobacterial agent-4 (compound 12) exerts antimycobacterial activity against the Mycobacterium tuberculosis H37Rv strain (MIC99=5 μM), and antiplasmodial activity against the Chloroquine (HY-17589A) sensitive NF54 Plasmodium falciparum strain (IC50=6.1 μM) and cytotoxicity on a mammalian cell line (CHO, IC50=2.2 μM)[1].Antimycobacterial agent-4 (compound 38) shows cytotoxicity against Vero cells with toxic concentration TC50 of 3.0 μM[2]. |
| Name | Antimycobacterial agent-4 |
| CAS | 476319-66-1 |
| Formula | C15H10N4O3S |
| Molar Mass | 326.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mjambili F, et al. Synthesis and biological evaluation of 2-aminothiazole derivatives as antimycobacterial and antiplasmodial agents. Bioorg Med Chem Lett. 2014 Jan 15;24(2):560-4. [2]. Kesicki EA, et al. Synthesis and Evaluation of the 2-Aminothiazoles as Anti-Tubercular Agents. PLoS One. 2016 May 12;11(5):e0155209. |
Antimycobacterial agent-4
CAS: 476319-66-1 F: C15H10N4O3S W: 326.33
Antimycobacterial agent-4 is a 2-amino-4-(2-pyridyl) thiazole derivative, with antimycobacterial activity, antiplasmodia
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