| Bioactivity | Anticancer agent 141 (compound AE) is an antimycin alkaloid, with inhibitory pottential in HPV infected-cervical cancer. Anticancer agent 141 inhibits cervical cancer HeLa cells proliferation, arrests cell cycle at S phase. Anticancer agent 141 induces caspase dependent apoptosis, via disrupting mitochondrial function, and then activating ROS-mediated ubiquitin-dependent proteasome system, thus mediating E6/E7 oncoproteins degradation[1]. |
| Target | E6/E7 oncoprotein |
| Invitro | Anticancer agent 141 (compound AE) (0.1 μM; 24 h) 显著降低 HeLa 细胞的 p53 和 Cyclin D1 水平。并抑制 PI3K、Akt 和 STAT3 的磷酸化，但对其总蛋白水平无影响[1]。Anticancer agent 141 (0.4 μM; 24 h) 通过增加 HeLa 细胞的 UPS 激活，而介导 E6/E7 降解[1]。 Anticancer agent 141 对 HeLa 细胞作用 24、48、72 h 的 IC50 值分别为 1.35、0.12、0.03 μM[1]。 0 --> Antimycin A2c 相关抗体: |
| Name | Antimycin A2c |
| Formula | C28H40N2O9 |
| Molar Mass | 548.63 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang W, et al. A novel antimycin analogue antimycin A2c, derived from marine Streptomyces sp., suppresses HeLa cells via disrupting mitochondrial function and depleting HPV oncoproteins E6/E7. Life Sci. 2023 Oct 1;330:121998. |