| Bioactivity | Antimicrobial agent-11 is a SARS-CoV-2 inhibitor with antibacterial activity[1]. |
| Target | Bacteria, SARS-CoV-2 |
| Invitro | Antimicrobial agent-11 (compound 5) shows inhibitory activity on coronavirus (SARS-CoV-2) replication and spike-mediated pseudovirus entry in Vero E6 cells and Calu-3 cells, with EC50 values of 24 μM, 57μM[1].Antimicrobial agent-11 inhibits Cathepsin L, 3CLPro enzyme activity and the ACE2-spike interaction, with EC50 values of 52 μM, 5 μM and 65 μM respectively[1]. Antimicrobial agent-11 (0-10 μg/mL approximately) shows activity against diverse species of Gram-positive bacteria[1].Antimicrobial agent-11 (0-100 μM, 2 h) inhibits SARS-CoV-2 pseudovirus entry in Vero and A549-AT cells[1]. Cell Viability Assay[1] Cell Line: |
| Name | Antimicrobial agent-11 |
| Formula | C77H61Cl2F17N8O24 |
| Molar Mass | 1876.23 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ilona Bereczki, et al. Semisynthetic teicoplanin derivatives with dual antimicrobial activity against SARS-CoV-2 and multiresistant bacteria. Sci Rep. 2022 Sep 26;12(1):16001. |