| Bioactivity | Antimicrobial agent-10 is a SARS-CoV-2 inhibitor with outstanding antibacterial activity[1]. |
| Target | Bacteria, SARS-CoV-2 |
| Invitro | Antimicrobial agent-10 (compound 4) shows inhibitory activity on coronavirus (SARS-CoV-2, HCoV-229E) replication and spike-mediated pseudovirus entry in Vero E6 cells, Calu-3 cells, A549-AT cells, with EC50 values of 13-22 μM[1].Antimicrobial agent-10 inhibits cathepsin L, 3CLPro enzyme activity and the ACE2-spike interaction, with EC50 values of 66 μM, 7.6 μM, 9 μM respectively[1]. Antimicrobial agent-10 (0-10 μg/mL approximately) shows activity against diverse species of Gram-positive bacteria including drug-resistant strains[1].Antimicrobial agent-10 (0-100 μM, 2 h) inhibits SARS-CoV-2 pseudovirus entry in Vero and A549-AT cells[1]. Cell Viability Assay[1] Cell Line: |
| Name | Antimicrobial agent-10 |
| Formula | C78H65Cl2F13N10O24 |
| Molar Mass | 1844.29 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ilona Bereczki, et al. Semisynthetic teicoplanin derivatives with dual antimicrobial activity against SARS-CoV-2 and multiresistant bacteria. Sci Rep. 2022 Sep 26;12(1):16001. |