Antimalarial agent 44_product_DataBase

Bioactivity	Antimalarial agent 44 (Compound 3) is an antimalarial agent against parasite. Antimalarial agent 44 has a good permeability across MDCK-MDR1 cell monolayers and a high clearance by mouse liver microsomes[1].
Invitro	Antimalarial agent 44 对 Leishmania infantum、Plasmodium falciparum、Trypanosoma brucei brucei、Trypanosoma brucei rhodesiense 和 Trypanosoma cruzi 均有抑制作用 (EC50 分别为 1.8、3、15、9.1 和 20 μM) [1]。Antimalarial agent 44 (pH 7.4) 在 MDCK-MDR1 细胞单层上具有良好的细胞渗透性，其Papp AB 为 3.5 μcm/s[1]。Antimalarial agent 44 (pH 7.4) 在小鼠肝脏微粒体中被高效清除，CLint大于 580 μL/min/mg[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Antimalarial agent 44 相关抗体:
Formula	C37H37N5O7
Molar Mass	663.72
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Riu, et al. Discovery of a Series of Macrocycles as Potent Inhibitors of Leishmania Infantum. Journal of medicinal chemistry, 2024, 67(20):18170-18193.

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