Antimalarial agent 37_product_DataBase

Bioactivity	Antimalarial agent 37 (compound 33) is a selective inhibitor against Type Ⅱ kinase with antiplasmodial activity. Antimalarial agent 37 exhibited cytotoxicity and selectivity towards cancer cells HepG2 and MCF 7[1].
Invitro	Antimalarial agent 37（0-50 nM，72 h）具有抗疟原虫活性，对于菌株 Dd2 和 3D7 的 EC50值是 31 nM 和 35 nM[1]。 Antimalarial agent 37 具有微粒体稳定性，在小鼠肝微粒体中的半衰期是 41.4 min，清除率是 17 μL/min/mg [1]。Antimalarial agent 37（0-5000 nM，48 h）对于细胞 HepG2 和 MCF7 具有细胞毒性，EC50 值是 2850 和 3540 nM[1]。 0 --> Antimalarial agent 37 相关抗体: Cell Proliferation Assay[1] Cell Line:
Name	Antimalarial agent 37
CAS	2982633-16-7
Formula	C32H29F6N5O2S
Molar Mass	661.66
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wang L, et al., Discovery of Potent Antimalarial Type II Kinase Inhibitors with Selectivity over Human Kinases. J Med Chem. 2024 Jan 12. doi: 10.1021/acs.jmedchem.3c02046

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