| Bioactivity | Antimalarial agent 23 is an antimalarial benzimidazole with IC50s of 0.08 μM and 0.10 μM for PfNF54 and PfK1, respectively. Antimalarial agent 23 has potent β-hematin inhibition activity. Antimalarial agent 23 does not directly inhibit the conversion of heme to hemozoin[1]. |
| Invitro | Antimalarial agent 23 (化合物 14) 对 CHO 细胞具有细胞毒性，IC50 为 37.3 μM[1]。 |
| Name | Antimalarial agent 23 |
| Formula | C24H23ClF3N5O |
| Molar Mass | 489.92 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Henrietta D Attram, et al. Antimalarial Imidazopyridines Incorporating an Intramolecular Hydrogen Bonding Motif: Medicinal Chemistry and Mechanistic Studies. ACS Infect Dis. 2023 Apr 14;9(4):928-942. |
Antimalarial agent 23
CAS: F: C24H23ClF3N5O W: 489.92
Antimalarial agent 23 is an antimalarial benzimidazole with IC50s of 0.08 μM and 0.10 μM for PfNF54 and PfK1, respecti
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