Antileishmanial agent-16_product_DataBase

Bioactivity	Antileishmanial agent-16 (compound 14c) is an anti-Leishmania agent. Antileishmanial agent-16 has superior anti-Leishmania major promastigotes activity (IC50 = 0.59 µM) and anti-Leishmania major amastigotes activity (IC50 = 0.81 µM). Antileishmanial agent-16 has good safety to mammalian cells (VERO cells)[1].
Target	Leishmania.
Invitro	Antileishmanial agent-16 (0-20 µM; 24 h) 显示出优越的抗 L. Major 前鞭毛体和无鞭毛体活性，其 IC50 值分别为 0.59 和 0.81 µM[1]。Antileishmanial agent-16 显示出对 L. amastigote 的高选择性及其对哺乳动物细胞（VERO 细胞）的安全性，SI 值为 311.4[1]。选择性指数 (SI)：体外细胞毒性（CC50，单位为 μM）与抗利什曼原虫无鞭毛体活性（IC50，单位为 μM）之比。 Cell Viability Assay[1] Cell Line:
Name	Antileishmanial agent-16
Formula	C27H37N5O4
Molar Mass	495.61
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Hassan NW, et al. Modulating leishmanial pteridine metabolism machinery via some new coumarin-1,2,3-triazoles: Design, synthesis and computational studies. Eur J Med Chem. 2023 May 5;253:115333.

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