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Antileishmanial agent-13

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Bioactivity Antileishmanial agent-13 is a quinoline-isatin hybrid, acts as an antileishmanial agent against L. Major Leishmania strain. Antileishmanial agent-13 acquires the antileishmanial activity via the anti-folate mechanism. Antileishmanial agent-13 has potent inhibition against both promastigote and amastigote forms with IC50s of 0.604 μM and 0.508 μM, respectively[1].
Invitro Antileishmanial agent-13 (化合物 4e) 对前鞭毛体的体外活性优于 Miltefosine (HY-13685) (IC50=7.8976 μ M)[1]。Antileishmanial agent-13 (2 μM; 48 h) 显示抗利什曼病活性,主要归因于抗叶酸机制,通过抑制 DHFR-TS 和 PTR1[1]。Antileishmanial agent-13 (0-100 μM; 72 h) 对非洲绿猴肾细胞 (VERO 细胞) 具有较低的细胞毒性,CC50 值为 155.8 μM[1]。
Name Antileishmanial agent-13
CAS 853725-86-7
Formula C17H10BrClN4O
Molar Mass 401.64
Transport Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

Reference [1]. Sabt A, et al. New antileishmanial quinoline linked isatin derivatives targeting DHFR-TS and PTR1: Design, synthesis, and molecular modeling studies[J]. European Journal of Medicinal Chemistry, 2022: 114959.

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