| Bioactivity | Antifungal agent 96 (Compound WZ-2) is an antifungal agent with good blood-brain barrier permeability and brain penetration. Antifungal agent 96 inhibits the growth of C. neoformans H99 and C. albicans 0304103 with MIC values of 0.016 and 32 μg/mL, respectively[1]. |
| Invitro | Antifungal agent 96 (0.063, 2μg/mL; 24 h) 显著抑制 C. neoformans H99 的荚膜生长[1]。Antifungal agent 96 (0.063μg/mL; 24h) 抑制了 C. neoformans H99 的生物膜形成，抑制率超过90%[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Antifungal agent 96 相关抗体: |
| In Vivo | Antifungal agent 96 (5 mg/kg; i.v.; daily; 3 days) 对小鼠中的 C. neoformans 和 C. albicans 显示出有效的抗真菌功效[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C11H8N2O3S |
| Molar Mass | 248.26 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yang W, et al. Discovery of New Tricyclic Oxime Sampangine Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcosis and Candidiasis. J Med Chem. 2024 Mar 28;67(6):4726-4738. |