| Bioactivity | Antifungal agent 43 (compound B05) is an antifungal agent. Antifungal agents 43 has antifungal activity by inhibiting biofilm formation. Antifungal agent 43 has low toxicity in human cancer cell lines[1]. |
| Invitro | Antifungal agent 43 (compound B05; 0.25-128 μg/mL) has antifungal activity against fungi strains with MIC values of 1, 1, 4, 4, 8, and 8 μg/mL for C.alb(sc5314), C.zey, C.alb, C.par, C.gla, and C.kru, respectively[1].Antifungal agent 43 (0.25-128 μg/mL) has antifungal activity against azole-resistant strains with MIC values of 2, 4, 4, 4, and 32 μg/mL for strain CaR, strain 632, strain 901, strain 904, and strain 17#, respectively[1].Antifungal agent 43 (0-10 μM) has low toxicity in human cancer cell lines with IC50 values of 5.04, 7.43 and 14.74 for MDA-MB-231, PC-3, and HL-60 cells, respectively[1]. |
| Name | Antifungal agent 43 |
| Formula | C24H26N4Se2 |
| Molar Mass | 528.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xu H, et, al. Discovery of novel selenium-containing azole derivatives as antifungal agents by exploiting the hydrophobic cleft of CYP51. Eur J Med Chem. 2022 Aug 28;243:114707. |