| Bioactivity | Anticancer agent 81 (Compound 37b3) is an anticancer agent and can induce tumor cell cycle arrest and apoptosis. Anticancer agent 81 can be used as a payload to conjugate with Trastuzumab (HY-P9907) to obtain the antibody–drug conjugate (ADC) T-PBA. T-PBA maintained its mode of target and internalization ability of Trastuzumab[1]. |
| Invitro | Anticancer agent 81 (Compound 37b3) (72 h) shows cytotoxicity against SKOV3, MDA-MB-231 and NCI-N87 cells[1].Anticancer agent 81 (0-5 μM) induces DNA interstrand cross-linking[1].Anticancer agent 81 (0-3 nM; 24 h) arrests SKOV3 cell cycle at the S-phase[1].Anticancer agent 81 (0-3 nM; 48 h) induces SKOV3 cell apoptosis[1].Anticancer agent 81 (25 nM; 12 h) acts on DNA in the nucleus after entering SKOV3 cells and MDA-MB-231 cells[1].Anticancer agent 81 induces DDR signaling pathways via cross-linking DNA and then activates the caspase cascade and PARP, finally leading to cell cycle arrest and apoptosis[1].Anticancer agent 81 covalently binds to the DNA sequences and acts on the major groove of DNA[1]. Cell Cytotoxicity Assay[1] Cell Line: |
| Name | Anticancer agent 81 |
| Formula | C46H46N6O5 |
| Molar Mass | 762.89 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |