Anticancer agent 71_product_DataBase

Bioactivity	Anticancer agent 71 (Compound 4b) is a potent anticancer agent and induces apoptosis. Anticancer agent 71 arrests cell cycle at G2/M phase and induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression levels. Anticancer agent 71 shows antiproliferative activity[1].
Invitro	Anticancer agent 71 (Compound 4b) (0.1-50 μM, 24 hours; SW480 and PC3 cells) increases the cytotoxicity and exerts potent antitumor activities against SW480 and PC3 cells[1].Anticancer agent 71 (Compound 4b) (11.08 μM, 24 hours; SW480 cells) induces a significant G2/M phase arrest[1].Anticancer agent 71 (Compound 4b) (11.08 μM, 24 hours) induces apoptosis in SW480 cells by upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression[1]. Cell Cytotoxicity Assay[1] Cell Line:
Name	Anticancer agent 71
CAS	2453228-45-8
Formula	C18H13ClF3N5O
Molar Mass	407.78
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

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