| Bioactivity | Anticancer agent 65 (compound 4c) shows excellent activity in cancer cell lines, especially A549 cells, with an IC50 of 1.07 μM. Anticancer agent 65 induces S-phase arrest in A549 cells and increases the expression level of p53 and p21. Anticancer agent 65 causes apoptosis, ROS generation and collapse of MMP in A549 cells[1]. |
| Invitro | Anticancer agent 65 (compound 4c) increases the expression of Bax and decrease that of Bcl-2[1]. |
| Name | Anticancer agent 65 |
| CAS | 2407861-48-5 |
| Formula | C36H63NO5 |
| Molar Mass | 589.89 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ma L, Wang X, Li W, Miao D, Li Y, Lu J, Zhao Y. Synthesis and anti-cancer activity studies of dammarane-type triterpenoid derivatives. Eur J Med Chem. 2020 Feb 1;187:111964. |
Anticancer agent 65
CAS: 2407861-48-5 F: C36H63NO5 W: 589.89
Anticancer agent 65 (compound 4c) shows excellent activity in cancer cell lines, especially A549 cells, with an IC50 of
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