| Bioactivity | Anticancer agent 64 (compound 5m) shows cytotoxic activity in CCRF-CEM cells, with IC50 of 2.4 μM. Anticancer agent 64 shows good anticancer activity through apoptosis induction. Anticancer agent 64 induces caspase 3 and 7 activation and PARP cleavage. Anticancer agent 64 induces significant effect of mitochondria depolarization[1]. |
| Invitro | Anticancer agent 64 (compound 5m) increases BAX expression and decreases Bcl-2 protein expression[1]..Anticancer agent 64 shows significant increasement in cells accumulation in the G2/M phase of the cell cycle, while proportion of cells in S phase is reduced[1]. |
| Name | Anticancer agent 64 |
| Formula | C31H46N2O2S |
| Molar Mass | 510.77 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |