| Bioactivity | Anticancer agent 54 is a potent anticancer agent. Anticancer agent 54 shows antiproliferative activity. Anticancer agent 54 induces apoptosis and cell cycle arrest at G0/G1 phases. Anticancer agent 54 shows anticancer activity depends on DNA intercalation and ROS generation[1]. |
| Invitro | Anticancer agent 54 (compound L) (0-25 µM; 72 h) shows antiproliferative activity with IC50s of 0.04, 0.44, 0.27, 0.14, 0.75, 20.83 µM for MCF-7, PANC-1, HCT116, U-251, A549, NHDF (normal human fifibroblast) clls, respectively[1].Anticancer agent 54 (1, 2.5, 5 µM; 24 h) induces cell cycle arrest at G0/G1 phases and apoptosis in a concentration-dependent manner[1].Anticancer agent 54 (1 µM; 24 h) increases the reactive oxygen species (ROS) level[1]. Cell Cycle Analysis[1] Cell Line: |
| Name | Anticancer agent 54 |
| Formula | C33H36N6 |
| Molar Mass | 516.68 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |