Anticancer agent 260_product_DataBase

Bioactivity	Anticancer agent 260 (Compound 3g/4d) is an orally active anticancer agent, that inhibits the proliferation of cancer cell HCT-116, MIA-PaCa2 and MDA-MB231 with IC50s of 98.7, 81.0, and 77.2 µg/mL, respectively. Anticancer agent 260 exhibits promotes ulcer formation and lipid peroxidation, anti-inflammatory and analgesic efficacy[1][2].
CAS	345994-70-9
Formula	C14H11N3O
Molar Mass	237.26
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Gilani SJ, et al., Synthesis and pharmacological evaluation of condensed heterocyclic 6-substituted 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives of isoniazid. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4762-5. [2]. Mutchu B R, et al. Bi (OTf) 3 PROMOTED MICROWAVE SYNTHESIS OF 2-ARYL, 5-SUBSTITUTED 1, 3, 4-OXADIAZOLES AND EVALUATION OF THEIR ANTICANCER ACTIVITY[J]. organic synthesis, 2019, 12(4): 2052-2057.

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