| Bioactivity | Anticancer agent 249 (Compound 89) is an inhibitor for Hsp90β with IC50 of 16.5 μM in PC3MM2 cell. Anticancer agent 249 inhibits proliferation of cancer cells MCF-7, T47D, MDA-MB-231, MDA-MB-468 and SKBr3 with IC50 of 1.8-5.3 μM. Anticancer agent 249 induces apoptosis in MDA-MB-231. Anticancer agent 249 exhibits antitumor efficacy in mice[1]. |
| Formula | C25H31Cl2N3O2 |
| Molar Mass | 476.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zajec Ž, et al., New Class of Hsp90 C-Terminal Domain Inhibitors with Anti-tumor Properties against Triple-Negative Breast Cancer. J Med Chem. 2024 Jul 23 |
Anticancer agent 249
CAS: F: C25H31Cl2N3O2 W: 476.44
Anticancer agent 249 (Compound 89) is an inhibitor for Hsp90β withIC50 of 16.5 μM in PC3MM2 cell. Anticancer agent 249
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