Anticancer agent 247_product_DataBase

Bioactivity	Anticancer agent 247 (Compound 22o) inhibits cell metastasis, induces cell apoptosis (increases the expression of Bax, p53, cleaved-caspase 3, and cleaved-PARP). Anticancer agent 247 decreases mitochondrial membrane potential. Anticancer agent 247 activates autophagy through the PI3K-Akt-mTOR signaling pathway, damages intracellular mitochondria and lysosomes, and cause ER stress. Anticancer agent 247 inhibits RPS6 phosphorylation. Anticancer agent 247 is an anticancer agent with low systemic toxicity[1].
Invitro	Anticancer agent 247 inhibits cancer cell growth, with IC50s of 3.82 μM (HCT-116), 2.80 μM (HeLa), 5.54 μM (MCF-7), 45.96 (A549), 32.71 μM (HepG2), 13.02 μM (PANC-1) respectively[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Anticancer agent 247 相关抗体:
Formula	C16H18Cl2N4O4S
Molar Mass	433.31
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Hao EJ, et al. Discovery, Synthesis, and Activity Evaluation of Novel Five-Membered Sulfur-Containing Heterocyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo. J Med Chem. 2024 Jul 17.

PeptideDB