| Bioactivity | Anticancer agent 235 (Compound 49) is a modulator for PI3K/AKT/mTOR pathway, that promotes the generation of ROS, reduces the mitochondrial membrane potential, and thereby inhibits the proliferation of cancer cells HCT116, Caco-2, AGS and SMMC-772 with IC50 of 0.35-26.9 μM. Anticancer agent 235 arrests the cell cycle at G2/M phase, and induces apoptosis in HCT116[1]. |
| CAS | 2411108-21-7 |
| Formula | C17H13ClN2O |
| Molar Mass | 296.75 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ma Y, et al. Synthesis and Biological Activity of 2-Chloro-8-methoxy-5-methyl-5 H-indolo [2, 3-b] Quinoline for the Treatment of Colorectal Cancer by Modulating PI3K/AKT/mTOR Pathways[J]. ACS Omega, 2024. |
Anticancer agent 235
CAS: 2411108-21-7 F: C17H13ClN2O W: 296.75
Anticancer agent 235 (Compound 49) is a modulator for PI3K/AKT/mTOR pathway, that promotes the generation of ROS, reduce
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