Anticancer agent 227_product_DataBase

Bioactivity	Anticancer agent 227 (compound YNU-1c) is a potent anticancer agent. Anticancer agent 227 shows antiproliferative activity. Anticancer agent 227 induces apoptosis and mitophagy[1].
Invitro	Anticancer agent 227 (compound YNU-1c) (0-50 µM; 48 h) 显示出抗增殖活性，对 HepG2、HCC1806、HL-7702 细胞的 IC50 值分别为 0.19、0.13、>50 µM[1]。Anticancer agent 227 (0.13 µM; 48 h) 通过增加细胞色素 c 和裂解 caspase-3 的表达来诱导细胞凋亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Anticancer agent 227 相关抗体: Cell Proliferation Assay[1] Cell Line:
In Vivo	Anticancer agent 227 (5 mg/kg; i.p.; every 2 days for 21 days) 在 HCC1806 荷瘤裸鼠中显示出抗肿瘤活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
Formula	C38H27Cl5N2O2PRh
Molar Mass	854.78
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Huang XQ, et al. Anticancer activity of 8-hydroxyquinoline-triphenylphosphine rhodium(III) complexes targeting mitophagy pathways. Eur J Med Chem. 2024 Jun 5;272:116478.

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