| Bioactivity | Anticancer agent 207 (compound 10b) is a potent anticancer agent. Anticancer agent 207 bounds to the NRAS rG4 with a KD value of 2.31 µM. Anticancer agent 207 shows cytotoxicity and decreases the expression of NRAS protein. Anticancer agent 207 shows antitumor activity[1]. |
| Invitro | Anticancer agent 207 (48 h) 对 NRAS 突变黑色素瘤 SK-MEL-2 显示出细胞毒性，IC50 值为 2.0 µM[1]。Anticancer agent 207 (0, 0.5, 1.0 µM; 72 h) 可降低 NRAS 蛋白的表达[1]。Anticancer agent 207 (0, 0.13, 0.25 µM; 10 days) 抑制 SK-MEL-2 细胞集落形成[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Anticancer agent 207 相关抗体: Western Blot Analysis[1] Cell Line: |
| In Vivo | Anticancer agent 207 (1 mg/kg; i.p.; every day for 21 days) 可抑制小鼠肿瘤的体积和重量[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C29H39FN4O2 |
| Molar Mass | 494.64 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jia-Wei Sun, et al. Design, synthesis, and evaluation of novel quindoline derivatives with fork-shaped side chains as RNA G-quadruplex stabilizers for repressing oncogene NRAS translation. European Journal of Medicinal Chemistry. 2024, 271(5): 116406. |