| Bioactivity | Anticancer agent 205 (compound 9) is a potent anticancer agent. Anticancer agent 205 binds to G4-mtDNA target and inhibits the replication, transcription, and translation of mtDNA (mitochondrial genome). Anticancer agent 205 causes mitochondrial dysfunction, increases ROS production, induces DNA damage and cellular senescence. Anticancer agent 205 induces apoptosis and cell cycle arrests at G0/G1 phase. Anticancer agent 205 has the potential for the research of colorectal cancer[1]. |
| Invitro | Anticancer agent 205 (compound 9) (4 µM; 1 h) 与 HCT116 细胞中的 G4-mtDNA 相互作用[1]。Anticancer agent 205 (0, 1, 2, 4 µM; 48 h) 可降低 HCT116、HFF1 细胞中 ND2 和 ND5 的 mRNA 水平[1]。Anticancer agent 205 (0, 1, 2, 4 µM; 48 h) 可降低 HCT116 细胞中 ND3、ND4、ND6、COX1、COX2、COX3、CYTB、ATP6 和 ATP8 的蛋白水平[1].Anticancer agent 205 (0-4 µM) 以浓度依赖性方式提高 ROS 水平[1]。Anticancer agent 205 (0-4 µM; 72 h) 会诱导 DNA 损伤和细胞衰老[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Anticancer agent 205 相关抗体: Cell Cytotoxicity Assay[1] Cell Line: |
| In Vivo | Anticancer agent 205 (5 mg/kg; i.v.; every 2 days for 16 days) 可抑制 HCT116 异种移植小鼠模型中的肿瘤生长[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C52H60I2N4 |
| Molar Mass | 994.87 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zheng BX, et al. Mitochondria-Selective Dicationic Small-Molecule Ligand Targeting G-Quadruplex Structures for Human Colorectal Cancer Therapy. J Med Chem. 2024 Apr 25;67(8):6292-6312. |