Anticancer agent 194_product_DataBase

Bioactivity	Anticancer agent 194 (compound 10p) is a ferroptosis and autophagy inducer. Anticancer agent 194 arrests colon cancer cell cycle at G2/M phase, but can't induce cell apoptosis. Anticancer agent 194 independently triggeres cell ferroptosis and autophagy through the massive accumulation of ROS[1].
Invitro	Anticancer agent 194（化合物 10p；1-10 μM；48 小时）对 HT-29 癌细胞具有抗增殖活性，IC50 为 1.97 μM[1]。 Anticancer agent 194（化合物 10p；1-4 μM；48 小时）以浓度依赖性方式将细胞周期阻滞在 G2/M 期[1]。 Anticancer agent 194（化合物 10p；0.5-4 μM；48 小时）以浓度依赖性方式降低 GPX4 的表达[1]。 Anticancer agent 194（化合物 10p；1-4 μM；48 小时）诱导 HT-29 细胞自噬[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Anticancer agent 194 相关抗体: Cell Viability Assay[1] Cell Line:
CAS	2767204-90-8
Formula	C12H16ClN3O2
Molar Mass	269.73
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Tingting Liang, et al. Discovery of novel urea derivatives as ferroptosis and autophagy inducer for human colon cancer treatment. Eur J Med Chem. 2024 Feb 24:268:116277.

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