Anticancer agent 114_product_DataBase

Bioactivity	Anticancer agent 114 is a potent and orally active dipeptide boronic acid ester proteasome inhibitor with an IC50 value of 2.2 nM. Anticancer agent 114 has antiproliferative activity against the RPMI-8226 cells. Anticancer agent 114 can be used in research of multiple myeloma[1].
Invitro	Anticancer agent 114 (compound 18u; 0-2 μM; 24 h) 对 RPMI-8226 细胞具有抗增殖活性，IC50 值为 5.6 nM[1]。 Cell Viability Assay[1] Cell Line:
In Vivo	Anticancer agent 114 (compound 18u; 6 and 10 mg/kg; p.o.; 每周两次, 持续 21 天) 在人 MM (RPMI-8226) 异种移植小鼠模型中表现出抗癌功效[1]。Anticancer agent 114 (0.4 mg/kg and 1.2 mg/kg; i.v and p.o.; 雄性 Sprague-Dawley 大鼠) 表现出良好的微粒体稳定性和药代动力学特性[1]。 Animal Model:
Name	Anticancer agent 114
Formula	C28H33BF6N2O7
Molar Mass	634.37
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wang X, et, al. Design and discovery of novel dipeptide boronic acid ester proteasome inhibitors, an oral slowly-released prodrug for the treatment of multiple myeloma. Eur J Med Chem. 2023 Mar 15;250:115187.

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