Anticancer agent 106_product_DataBase

Bioactivity	Anticancer agent 106 (compound 10ic) is an anticancer agent that induces apoptosis in B16-F10 melanoma cells. Anticancer agent 106 also potently inhibits metastatic nodules in a mouse model of lung metastatic melanoma. Anticancer agent 106 can be used in the study of cancer, especially lung metastatic melanoma[1].
Invitro	Anticancer agent 106 (化合物 10ic; 0.28-55 μM; 24 h) 以剂量依赖性方式降低 B16-F10 黑色素瘤细胞的活力，IC50 值为 4.8 μM[1]。Anticancer agent 106 (5-20 μM; 48 h) 诱导 B16-F10 黑色素瘤细胞凋亡[1]。 Cell Viability Assay[1] Cell Line:
In Vivo	Anticancer agent 106 (9-9.5 mg/kg; i.p.; every 3rd d for 22 d) 抑制肺转移性黑色素瘤小鼠模型中的转移性结节[1]。 Animal Model:
Name	Anticancer agent 106
Formula	C26H25N3O4S
Molar Mass	475.56
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Anna Rogova, et al. Synthesis of thieno[3,2-e]pyrrolo[1,2-a]pyrimidine derivatives and their precursors containing 2-aminothiophenes fragments as anticancer agents for therapy of pulmonary metastatic melanoma. Eur J Med Chem. 2023, 254: 115325.

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