Antibacterial agent 237

CAS: F: C65H69Cl3N10RuS2 W: 1261.87

Antibacterial agent 237 (compound Ru-8) is a bacteriostatic agent for Staphylococcus aureus, with MIC of 0.78-1.56 μg/m

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Bioactivity	Antibacterial agent 237 (compound Ru-8) is a bacteriostatic agent for Staphylococcus aureus, with MIC of 0.78-1.56 μg/mL. Antibacterial agent 237 destroys bacterial cell membranes, changes their permeability, and induces bacteria to produce Reactive Oxygen Species, leading to bacterial death without causing drug resistance. Antibacterial agent 237 has low hemolytic toxicity to rabbit red blood cells and Raw 264.7 cells, and has significant antibacterial effects against Staphylococcus aureus in mouse skin wound infection models and Bacillus major larvae infection models[1].
Invitro	Antibacterial agent 237 对 S. aureus Newman，S. aureus ATCC 29213，Methicillin-resistant S. aureus ATCC 33591，E. coli 25922，PAO1 有抗菌作用，MIC 为 0.78 μg/mL，1.56 μg/mL，1.56 μg/mL，100 μg/mL，50 μg/mL[1]。Antibacterial agent 237 在高盐浓度下仍然保持抑制 S. aureus Newman 的活性，MIC 为 0.78 μg/mL，且在哺乳动物体液 (血清，血浆，血液) 中保持稳定性[1]。Antibacterial agent 237 (0-4.68 μg/mL，0-120 min) 能够高效快速杀伤 S. aureus Newman，且具有浓度依赖性，有效避免产生耐药性[1]。Antibacterial agent 237 (0-49.92 μg/mL，24 h) 可去除 S. aureus Newman 的生物膜，且呈剂量依赖效应[1]。Antibacterial agent 237 (0.39 μg/mL，5-6 h) 不易诱导 S. aureus Newman 耐药[1]。Antibacterial agent 237 (0.78-4.68 μg/mL，0-6 h) 破坏 S. aureus Newman 细胞膜，产生 ROS，使细菌内容物渗漏，导致细菌死亡[1]。Antibacterial agent 237 (0-100 μg/mL，24 h) 对 S. aureus Newman 有杀伤作用且不损伤正常细胞[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Antibacterial agent 237 相关抗体: Cell Viability Assay[1] Cell Line:
In Vivo	Antibacterial agent 237 (0-256 mg/kg，注射在尾巴的第二对腹足处) 在大蜡杆菌幼虫模型中显示出良好的药物安全性，且对大蜡杆菌幼虫体内感染有良好的治疗效果[1]。Antibacterial agent 237 (50，100 μg/mL，涂抹无菌乳膏) 对 S. aureus Newman 感染的小鼠模型有良好的治疗效果[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
Formula	C65H69Cl3N10RuS2
Molar Mass	1261.87
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wei Deng , et al. Discovery of quaternized pyridine-thiazole-ruthenium complexes as potent anti-Staphylococcus aureus agents. Eur J Med Chem. 2024 Nov 5:277:116712.

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