| Bioactivity | Antibacterial agent 205 (Compound 10d) is a indolylacryloyl-derived oxacins, which exhibits broad antibacterial spectrum with MIC of 0.25-0.5 μg/mL. Antibacterial agent 205 reduces the exopolysaccharide, eliminates the biofilm, and thus attenuates the drug resistance. Antibacterial agent 205 exhibits antibacterial activity through destory of membrane integrity, accumulation of reactive oxygen species ROS, and inhibition of DNA replication[1]. |
| Invitro | Antibacterial agent 205 对 Enterococcus，Staphylococcus，Escherichia，Acinetobacter 和 Pseudomonas 菌株具有抗菌性，MIC 为 0.25-0.5 μg/mL[1]。Antibacterial agent 205 (0-256 μg/mL) 具有低溶血作用，对血液、人肝细胞 (LO2) 和 HUVECs 具有低细胞毒性，与红细胞具有良好的相容性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Antibacterial agent 205 相关抗体: Cell Viability Assay[1] Cell Line: |
| Formula | C32H30FN5O6 |
| Molar Mass | 599.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hu YG, et al., Discovery of indolylacryloyl-derived oxacins as novel potential broad-spectrum antibacterial candidates. Eur J Med Chem. 2024 Apr 15;270:116392. |
Antibacterial agent 205
CAS: F: C32H30FN5O6 W: 599.61
Antibacterial agent 205 (Compound 10d) is a indolylacryloyl-derived oxacins, which exhibits broad antibacterial spectrum
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