Antibacterial agent 166

CAS: F: C11H8ClN3O4 W: 281.65

Antibacterial agent 166 (Compound 19q), a derivative of Nitisinone (HY-B0607), is a selective and orally active Fusobact

Contact QiTai

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	Antibacterial agent 166 (Compound 19q), a derivative of Nitisinone (HY-B0607), is a selective and orally active Fusobacterium nucleatum inhibitor with a MIC50 of 1 μg/mL. Antibacterial agent 166 effectively attenuates the migratory ability of MC-38 cells induced by Fusobacterium nucleatum. Antibacterial agent 166 is a promising anti-F. nucleatum lead compound and can be used for colorectal cancer (CRC) research[1].
Invitro	Antibacterial agent 166 (Compound 19q) (1-4μg/mL, 0-72 h) 能以剂量依赖的方式抑制 Fusobacterium nucleatum 的生长和生物膜的形成[1]。Antibacterial agent 166 (1-4 μg/mL, 4-48 h) 通过下调 NTR 的表达来抑制 Fusobacterium nucleatum 的生长[1]。Antibacterial agent 166 (1-4 μg/mL, 48 h) 在对数后期以剂量依赖的方式下调 tnaA 基因的表达[1]。Antibacterial agent 166 (2-4 μg/mL, 48 h) 在 Fusobacterium nucleatum 的刺激下，对 MC-38 细胞具有更强的迁移抑制能力[1]。Antibacterial agent 166对 MC-38 细胞表现出有效的抑制活性，IC50 为11 μM[1]。Antibacterial agent 166对两种人类正常细胞系具有中度至弱的抗增殖活性，IC50 为16 μM，具有较低的细胞毒性[1]。 0 --> Antibacterial agent 166 相关抗体: Real Time qPCR[1] Cell Line:
In Vivo	Antibacterial agent 166 (Compound 19q) (1500 mg/kg, 单次给药) 对器官的毒副作用很小[1]。Antibacterial agent 166 (20 mg/kg, 口服, 单次给药) 能在肠道局部抑制 Fusobacterium nucleatum，且具有较低的全身毒性[1]。Antibacterial agent 166 (1 mg/kg, 静脉注射) 半衰期约为0.068 h, 峰值浓度Cmax和血浆清除率(CL) 分别为85 ng/mL和36054 mL/h/mg[1]。
Name	Antibacterial agent 166
Formula	C11H8ClN3O4
Molar Mass	281.65
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Pan Z, et al. Discovery of New Fusobacterium nucleatum Inhibitors to Attenuate Migratory Capability of Colon Cancer Cells by the Drug Repositioning Strategy. Journal of Medicinal Chemistry. 2023 Nov 20.

Ammonium chloride, for cell culture