Antibacterial agent 140 chloride

CAS: F: C61H44Cl2N8Ru2- W: 1162.10

Antibacterial agent 140 chloride is a promising antibacterial agent. Antibacterial agent 140 chloride is also the first

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Bioactivity	Antibacterial agent 140 chloride is a promising antibacterial agent. Antibacterial agent 140 chloride is also the first Ru-based AIEgen photosensitizer for simultaneous dual applications of Gram-positive bacteria (G+) detection and treatment. Antibacterial agent 140 chloride uniquely selective discriminates and efficient exterminates Gram-positive bacteria (G+) from other bacteria due to its interaction with lipoteichoic acids (LTA). Antibacterial agent 140 chloride also possessed robust antibacterial activity for G+ under light irradiation[1].
Invitro	Antibacterial agent 140 chloride (0.1-5 μg/mL, 1 h) 在黑暗中表现出 78%-0% 的剂量依赖性，表明 Ru2 对 S. aureus 具有暗毒性[1]。Antibacterial agent 140 chloride（0.1-5 μg/mL；1 h) 在 120s 光照射下表现出明显的剂量依赖性和时间依赖性，Ru2 在极低浓度光照射下几乎完全抑制金黄色葡萄球菌的生长[1]。Antibacterial agent 140 chloride（0.1-5 μg/mL；1 h) 与 HeLa 细胞孵育后，80% 以上的 HeLa 细胞存活, 在 ≤32 μM 的光照下，>73% 的 HeLa 细胞存活[1]。
In Vivo	Antibacterial agent 140 chloride（20 μg/mL/50 μL; 1-10 days) 治疗使得金黄色葡萄球菌感染导致的伤口大小明显减小，雌性昆明小鼠伤口在 7 天后几乎完全愈合。 Animal Model:
Name	Antibacterial agent 140 chloride
Formula	C61H44Cl2N8Ru2-
Molar Mass	1162.10
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Mengling Liu, et al. Specific discrimination and efficient elimination of gram-positive bacteria by an aggregation-induced emission-active ruthenium (II) photosensitizer. Eur J Med Chem. 2023 May 5;251:115249.

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