Antibacterial agent 131_product_DataBase

Bioactivity	Antibacterial agent 131 is a quinoline derivative. Antibacterial agent 131 has antimicrobial effect. Antibacterial agent 131 destroys the integrity of the fungal cells via blocking ergosterol production[1].
Invitro	Antibacterial agent 131 (compound 4m) 具有抗菌活性，对 Escherichia coli ATCC 35218、E. coli ATCC 25922、Staphylococcus aureus ATCC 6538、和 methicillin-resistant S. aureus (MRSA) 的 MIC90 值分别为9.81 μg/mL[1]。Antibacterial agent 131 具有抗念珠菌作用，对 Candida krusei ATCC 6258、Candida parapsilosis ATCC 22019、Candida albicans ATCC 24433、和 C. glabrata ATCC 90030 的 MIC90 值分别为 ≤0.06、0.24、1.95、1.95 μg/mL[1]。Antibacterial agent 131 (24 h) 具有低细胞毒性，在 NIH/3T3 细胞中的 IC50 值为 34.51 μM[1]。Antibacterial agent 131 (0.06-3.91 μg/mL) 抑制针对大肠杆菌的 DNA 促旋酶[1]。Antibacterial agent 131 通过阻断麦角甾醇的产生而具有抗真菌活性[1]。
Name	Antibacterial agent 131
Formula	C24H17ClN4OS
Molar Mass	444.94
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

PeptideDB