Antibacterial agent 128_product_DataBase

Bioactivity	Antibacterial agent 128 is a siderophore analog-Ciprofloxacin (Ciprofloxacin (HY-B0356)) conjugate with a cleavable linker. Antibacterial agent 128 shows antibiotic activities against P. aeruginosa (MIC values of 0.25-64 μg/mL) and B. pseudomallei (MIC values of 1-32 μg/mL)[1].
Invitro	Antibacterial agent 128 (compound 2d)，带有一个带有可裂解接头的羟基吡啶酮部分，对铜绿假单胞菌 (P. aeruginosa) (MIC = 0.25-64 μg/mL)、类鼻疽伯克氏菌 (B. pseudomallei) (MIC = 1-32 μg/ mL) 和泰国伯克霍尔德氏菌 (B. thailandensis) (MIC = 4-128 μg/mL)。此外，Antibacterial agent 128 对铜绿假单胞菌环丙沙星耐药菌株 AM85 有活性，且无细胞毒性[1]。使用铁转运系统是一种很有前途的策略，可以绕过细菌细胞膜并恢复传统抗生素（如环丙沙星）的活性。铁载体类似物对应于假单胞菌属和伯克霍尔德氏菌属识别的单邻苯二酚或羟基吡啶酮部分。物理化学研究表明 (i) 结合物不能通过被动扩散相互作用或穿过膜，以及 (ii) 带有可裂解接头的结合物在生理环境中是稳定的[1]。
Name	Antibacterial agent 128
Formula	C26H25FN4O9
Molar Mass	556.50
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

PeptideDB