| Bioactivity | Antibacterial agent 127 (Compound 23) is a potent antibacterial agent[1]. |
| Target | Bacterial |
| Invitro | Antibacterial agent 127 (Compound 23) (0-64 μg/mL; 20 h) 表现出抗细菌活性，对MSSA ATCC29213、MSSA ATCC25923、MRSAb、MRSEb、E.coli ATCC25922 和 S.pullorum 的 MIC 分别为 0.063、0.063、0.063、0.25、32 和 64 μg/mL[1]。Antibacterial agent 127 具有良好的代谢稳定性 (在大鼠肝微粒体的 t1/2 为 3.25 min)[1]。Antibacterial agent 127 对 CYP3A4 (咪达唑仑) 和 CYP3A4 (睾酮) 有中等抑制作用，IC50 值分别为 2.64 和 1.94 μM[1]。 |
| In Vivo | Antibacterial agent 127 (Compound 23) (50 mg/kg; i.p.; single dose) 在小鼠大腿感染模型中有效抑制 MRSA[1]。 Animal Model: |
| Name | Antibacterial agent 127 |
| Formula | C28H37N3O5S |
| Molar Mass | 527.68 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Deng Y, et al. Antibacterial activity evaluation of pleuromutilin derivatives with 4(3H)-quinazolinone scaffold against methicillin-resistant Staphylococcusaureus. Eur J Med Chem. 2022 Nov 23;246:114960. |