| Bioactivity | Antibacterial agent 117, triazole derivative, is an antibacterial agent. Antibacterial agent 117 has against R. prowazekii MetAP1 (RpMetAP1) activity with an IC50 value of 15 μM. Antibacterial agent 117 also inhibits rickettsial growth and can be used for the research of infection[1]. |
| Target | IC50: 15 μM (RpMetAP1) |
| Invitro | Antibacterial agent 117 can inhibit RpMetAP1 with an IC50 value of 15 μM[1].Antibacterial agent 117 (0.3 μM, 3 μM, 30 μM and 300 μM) stimulates endothelial cell (EC) metabolism and also inhibits rickettsial growth[1]. |
| Name | Antibacterial agent 117 |
| CAS | 341944-06-7 |
| Formula | C9H9ClN4S |
| Molar Mass | 240.71 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Travis R Helgren, et al. Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents. Bioorg Med Chem |
Antibacterial agent 117
CAS: 341944-06-7 F: C9H9ClN4S W: 240.71
Antibacterial agent 117, triazole derivative, is an antibacterial agent. Antibacterial agent 117 has against R. prowazek
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