| Bioactivity | Antibacterial agent 105 (Compound 17) is a phenanthrolinic analog of quinolones show antibacterial activity against M. tuberculosis with antibacterial activity (MIC90=2.64 μM)。Antibacterial agent 105 exhibits antibacterial activities against different bacterial species with MIC90s of 11.18, 11.18，0.70，1.40，44.70, and 22.35 μM for M. smegmatis, M. aurum, M. marinum,BCG, E. aerogenes and S. aureus, respectively[1]. |
| Invitro | Antibacterial agent 105 (compound 17) has inhibitory effect on the growth of M. tuberculosis replicating in vitro cultured macrophages[1].Antibacterial agent 105 (compound 17) (24 hours) has no toxicity on Vero cells line and human macrophages[1].Antibacterial agent 105 (compound 17) has antibacterial activities against FQ resistant bacteria and XDR-TB[1]. |
| Name | Antibacterial agent 105 |
| CAS | 2364493-24-1 |
| Formula | C14H9N3O5 |
| Molar Mass | 299.24 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Songuigama Coulibaly, et al. Phenanthrolinic analogs of quinolones show antibacterial activity against M. tuberculosis. Eur J Med Chem. 2020 Dec 1;207:112821. |
Antibacterial agent 105
CAS: 2364493-24-1 F: C14H9N3O5 W: 299.24
Antibacterial agent 105 (Compound 17) is a phenanthrolinic analog of quinolones show antibacterial activity against M. t
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