| Bioactivity | Antiangiogenic agent 3 (compound 3) is a potent antiangiogenic agent. Antiangiogenic agent 3 is an inhibitor of human umbilical vein endothelial cells (HUVEC). Antiangiogenic agent 3 inhibits HUVEC migration and chemotactic motilities. Antiangiogenic agent 3 also decreases the gene expression of Src, cdc42, and MAPK[1]. |
| Invitro | Antiangiogenic agent 3 (6.25-200 μM；48 小时) 降低人脐静脉内皮细胞 (HUVEC) 的细胞活力[1]。Antiangiogenic agent 3 (5 μM, 10 μM; 24 h) 抑制 VEGF 诱导的 HUVEC 迁移或趋化运动，在 5 μM 和 10 μM 时抑制率分别为 30% 和 33%[1]。Antiangiogenic agent 3 (10 μM; 24 h) 下调与上皮细胞迁移相关的Src、cdc42和MAPK基因表达[1]。 RT-PCR[1] Cell Line: |
| Name | Antiangiogenic agent 3 |
| Formula | C19H20O7 |
| Molar Mass | 360.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gamage C D B, et al. Phthalides Isolated from the Endolichenic Arthrinium sp. EL000127 Exhibits Antiangiogenic Activity[J]. ACS Omega, 2023. |