Anti-inflammatory agent 53_product_DataBase

Bioactivity	Anti-inflammatory agent 53 (compound 7c) is an orally active selective COX-2 inhibitor. Anti-inflammatory agent 52 has anti-HT29 transfer activity, which leads to periodic arrest in S phase and G2/M phase. Anti-inflammatory agent 52 has safety, moderate ability to suppress inflammation. Anti-inflammatory agent 52 has a rare property of suppressing the development of tumor in mouse model, showing anti-cancer activity[1].
Target	COX-2
Invitro	Anti-inflammatory agent 53 (compound 7c) (0.25 μM; 24 h) 抑制 HT29 细胞集落形成，使细胞周期停滞在 G2/M 期和 S 期[1]。 0 --> Anti-inflammatory agent 53 相关抗体:
In Vivo	Anti-inflammatory agent 53 (compound 7c) (50 mg/kg；口服；每隔一天，持续两周) 可减少艾利希实体癌小鼠的肿瘤体积和重量[1]。
Name	Anti-inflammatory agent 53
Formula	C24H22N2O4S
Molar Mass	434.51
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Shawky AM, et al. Discovery and optimization of 2,3-diaryl-1,3-thiazolidin-4-one-based derivatives as potent and selective cytotoxic agents with anti-inflammatory activity. Eur J Med Chem. 2023 Nov 5;259:115712.

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