Anti-inflammatory agent 51_product_DataBase

Bioactivity	Anti-inflammatory agent 51 (compound 11d) is an amide/sulfonamide derivative with anti-inflammatory activities. Anti-inflammatory agent 51 inhibits NF-κB activation, has the potential for acute lung injury and ulcerative colitis research[1].
Invitro	Anti-inflammatory agent 51 (compound 11d) 有效减少 IL-6（IC50 值为 0.61 μM）和 TNF-α（IC50 为 4.34μM）的释放，并降低 J774A.1 细胞中细胞因子的 mRNA 水平。Anti-inflammatory agent 51 恢复 IκBα 并抑制磷酸化 p65 转位至细胞核[1]。
In Vivo	Anti-inflammatory agent 51 (compound 11d) 可改善 LPS 诱导的急性肺损伤 (ALI) 并减轻 DSS 诱导的小鼠溃疡性结肠炎[1]。
Name	Anti-inflammatory agent 51
CAS	2911610-03-0
Formula	C22H22N6O6S
Molar Mass	498.51
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Pan Chen, et al. Design, synthesis, and bioactivity evaluation of novel amide/sulfonamide derivatives as potential anti-inflammatory agents against acute lung injury and ulcerative colitis. Eur J Med Chem. 2023 Aug 2;259:115706.

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