| Bioactivity | Anti-inflammatory agent 36 is an anti-inflammatory agent. Anti-inflammatory agent 36 inhibits LPS-induced macrophage activation[1]. | ||||||||||||
| Invitro | Anti-inflammatory agent 36 (化合物 5a28) (2.5-20 μM) 抑制 LPS 诱导的活化 RAW 264.7 小鼠巨噬细胞中 TNF-α 和 IL-6 的释放，IC50 为 3.69 (TNF-α) 和 3.68 µM (IL-6)[1]。Anti-inflammatory agent 36 (10 μM，0.5 小时) 抑制 RAW 264.7 小鼠巨噬细胞中 LPS 诱导的 P-P38 和 P-ERK[1]。Anti-inflammatory agent 36 (10 μM, 0.5 h) 抑制 LPS 诱导的 TNF-α、IL-6、IL-1β、ICAM-1 和 VCAM-1 的转录[1]。 Western Blot Analysis[1] Cell Line: | ||||||||||||
| In Vivo | Anti-inflammatory agent 36 (化合物 5a28) (10 mg/kg，腹腔注射) 抑制急性肺损伤小鼠模型的炎症[1]。 Animal Model: | ||||||||||||
| Name | Anti-inflammatory agent 36 | ||||||||||||
| CAS | 2293951-01-4 | ||||||||||||
| Formula | C25H27NO7 | ||||||||||||
| Molar Mass | 453.48 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Qian J, et al. Design and synthesis novel di-carbonyl analogs of curcumin (DACs) act as potent anti-inflammatory agents against LPS-induced acute lung injury (ALI). Eur J Med Chem. 2019 Apr 1;167:414-425. |
Anti-inflammatory agent 36
CAS: 2293951-01-4 F: C25H27NO7 W: 453.48
Anti-inflammatory agent 36 is an anti-inflammatory agent. Anti-inflammatory agent 36 inhibits LPS-induced macrophage act
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.