Anti-inflammatory agent 33_product_DataBase

Bioactivity	Anti-inflammatory agent 33 is a potent p38α inhibitor. Anti-inflammatory agent 33 inhibits NO production. Anti-inflammatory agent 33 inhibits LPS-induced iNOS, COX-2, p-p38α, p-MK2 protein expression. Anti-inflammatory agent 33 shows anti-inflammatory activity[1].
Invitro	Anti-inflammatory agent 33 (compound 8j) (10, 5, 2.5, 1.25, 0.675 μM; 1+24 h) 在 LPS 诱导的 RAW264.7 细胞中显着抑制 NO 的产生，抑制率为93.97%，IC50 值为 1.25 µM[1]。Anti-inflammatory agent 33 (1.25, 2.5, 5, 10, 20 µM; 1+24 h) 抑制 TNF-α 和 IL-1β 的产生，IC50 值分别为 11.5, 8.48 μM[1]。Anti-inflammatory agent 33 (1, 3, 5 µM; 1+24 h) 在 RAW264.7 细胞中呈剂量依赖性抑制 LPS 诱导的 iNOS、COX-2、p-p38α、p-MK2 蛋白的表达[1]。 Western Blot Analysis[1] Cell Line:
In Vivo	Anti-inflammatory agent 33 (10, 30 mg/kg; once a day for 14 days) 在大鼠体内表现出剂量依赖性的抗炎活性[1]。 Animal Model:
Name	Anti-inflammatory agent 33
CAS	2816993-09-4
Formula	C22H15N3O5S
Molar Mass	433.44
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Du J, et al. Novel tryptanthrin derivatives with benzenesulfonamide substituents: Design, synthesis, and anti-inflammatory evaluation. Eur J Med Chem. 2022 Nov 25;246:114956.

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