Anti-inflammatory agent 17_product_DataBase

Bioactivity	Anti-inflammatory agent 17 is a potent and orally active anti-inflammatory agent. Anti-inflammatory agent 17 inhibits the release of IL-6 and TNF-α in vitro experiments without cytotoxicity. Anti-inflammatory agent 17 exhibits anti-inflammatory activity in vivo. Anti-inflammatory agent 17 has the potential for the research of Acute lung injury (ALI)[1].
Invitro	Anti-inflammatory agent 17 (compound 5b) (10 µM; 24 h) displays no toxicity in J774a.1 cells[1].Anti-inflammatory agent 17 (1.25, 2.5, 5, 10 µM; 2 h) inhibits the production of IL-6 (IC50=8.254 µM) and TNF-α (IC50=2.576 µM) in J774a.1 cells in a dose-dependent manner[1]. Cell Viability Assay[1] Cell Line:
In Vivo	Anti-inflammatory agent 17 (20 mg/kg; intragastric administration) exhibits protective effect on LPS (lipopolysaccharide)-induced ALI in mice[1]. Animal Model:
Name	Anti-inflammatory agent 17
CAS	2763226-84-0
Formula	C20H23NO5
Molar Mass	357.40
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wang X,et al. Design, synthesis and bioactivity evaluation of fisetin derivatives as potential anti-inflammatory agents against LPS-induced acute lung injury. Bioorg Med Chem. 2021; 49:116456.

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