| Bioactivity | Anti-MRSA agent 20 (Compound a4) is an anti-microbial agent (MIC: < 0.03125 μg/mL) against MRSA). Anti-MRSA agent 20 binds to the ribosomal peptidyl transferase center and inhibits bacterial survival by inhibiting MRSA toxin synthesis and bacterial division. Anti-MRSA agent 20 significantly reduces the MRSA load in the lungs and attenuates lung injury in the MRSA-infected mice (ED50 = 6.48 mg/kg)[1]. |
| Invitro | Anti-MRSA agent 20 抑制 Staphylococcus aureus ATCC 29213、MRSA ATCC 43300 和 MRSE ATCC 51625 生长，其最小抑菌浓度 (MIC) 低于 0.03125 μg/mL[1]。Anti-MRSA agent 20 (1 × MIC-6 × MIC, 0-24 h) 在时间-致死动力学实验中对 MRSA 具有抑制活性[1]。Anti-MRSA 20 (21 天) 可减缓细菌耐药性的产生，在第 17-18 天达到 8 μg/mL 的 MIC 值[1]。Anti-MRSA agent 20 (LC50 为 165.0 μg/mL) 仅在高浓度范围 (> 120 μg/mL) 对 HEK293 和 HEPG2 细胞有毒性，在低浓度范围 (0.5-1 μg/mL) 抑制 MRSA 毒素的合成，对斑马鱼胚胎无明显致畸作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Anti-MRSA agent 20 相关抗体: Cell Viability Assay[1] Cell Line: |
| In Vivo | Anti-MRSA agent 20 (2.5-40 mg/kg, 腹腔注射, 细菌感染后 1 h) 减少 MRSA 感染小鼠肺部细菌负荷，减轻肺部病变，增加其存活率[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C34H47NO8S2 |
| Molar Mass | 661.87 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yi, et al. Design, synthesis, and biological evaluation of novel pleuromutilin derivatives with methicillin-resistant Staphylococcus aureus -targeting phenol linker groups. European journal of medicinal chemistry, 2025, 282, 117061. |