| Bioactivity | Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells[1]. | ||||||||||||
| Target | Ca2+-activated Cl- currents | ||||||||||||
| Invitro | Anthracene-9-carboxylic acid causes a voltage-dependent block of outward currents in HEK 293T cells and inhibits a larger fraction of the current as depolarization increased[1].Anthracene-9-carboxylic acid induces a strong potentiation of tail currents measured at -100 mV after depolarizing voltages, as well as a prolongation of the deactivation kinetics in HEK 293T[1].Anthracene-9-carboxylic acid (500 μM, rabbit pulmonary artery smooth muscle cells) produces a small inhibition of the maximum outward Cl- current at +70 mV (21±10%) but augmented the amplitude of the instantaneous inward relaxation at -80 mV by 321±34%[2]. | ||||||||||||
| Name | Anthracene-9-carboxylic acid | ||||||||||||
| CAS | 723-62-6 | ||||||||||||
| Formula | C15H10O2 | ||||||||||||
| Molar Mass | 222.24 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Cherian OL, Menini A, Boccaccio A. Multiple effects of anthracene-9-carboxylic acid on the TMEM16B/anoctamin2 calcium-activated chloride channel. Biochim Biophys Acta. 2015 Apr;1848(4):1005-13. [2]. Piper AS, Greenwood IA. Anomalous effect of anthracene-9-carboxylic acid on calcium-activated chloride currents in rabbit pulmonary artery smooth muscle cells. Br J Pharmacol. 2003 Jan;138(1):31-8. |
Anthracene-9-carboxylic acid
CAS: 723-62-6 F: C15H10O2 W: 222.24
Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and i
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