| Bioactivity | Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy[1][2]. | ||||||
| Invitro | Antagonist G (0-100 μM) induces apoptosis is redox-sensitive and caspase-dependently in SCLC cells[2].Antagonist G activates JNK1 in SCLC cells[2].Antagonist G is not intrinsically a free radical oxygen donor but stimulates free radical generation specifically within SCLC cells (6.2-fold) and increases the activity of the redox-sensitive transcription factor AP-1 by 61%[2]. Cell Viability Assay[2] Cell Line: | ||||||
| Name | Antagonist G | ||||||
| CAS | 115150-59-9 | ||||||
| Shortening | RW-{Me-Phe}-WLM-NH2 | ||||||
| Formula | C49H66N12O6S | ||||||
| Molar Mass | 951.19 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
Antagonist G
CAS: 115150-59-9 F: C49H66N12O6S W: 951.19
Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonis
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