| Bioactivity | Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1]. |
| Invitro | Angoline (0-100 μM; 1 h) inhibits STAT3, STAT1 and NF-κB signaling pathways with IC50 values of 11.56, ＞100 and ＞100 μM, respectively[1].Angoline (0-100 μM; 2 h) affects phosphorylation of STAT3[1].Angoline (0-100 μM; 72 h) inhibits MDA-MB-231, H4 and HepG2 cells proliferation[1]. Western Blot Analysis[1] Cell Line: |
| Name | Angoline |
| CAS | 21080-31-9 |
| Formula | C22H21NO5 |
| Molar Mass | 379.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |