| Bioactivity | Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1]. |
| Invitro | Angoline hydrochloride (0-100 μM; 1 h) inhibits STAT3, STAT1 and NF-κB signaling pathways with IC50 values of 11.56, ＞100 and ＞100 μM, respectively[1].Angoline hydrochloride (0-100 μM; 2 h) affects phosphorylation of STAT3[1].Angoline hydrochloride (0-100 μM; 72 h) inhibits MDA-MB-231, H4 and HepG2 cells proliferation[1]. Western Blot Analysis[1] Cell Line: |
| Name | Angoline hydrochloride |
| CAS | 1071676-04-4 |
| Formula | C22H22ClNO5 |
| Molar Mass | 415.87 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Angoline hydrochloride
CAS: 1071676-04-4 F: C22H22ClNO5 W: 415.87
Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoli
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