Androsta-1,4,6-triene-3,17-dione_product_DataBase

Bioactivity	Androsta-1,4,6-triene-3,17-dione is a lipophilic and specific aromatase inhibitor with a Ki of 0.18 μM. Androsta-1,4,6-triene-3,17-dione inhibits estrogen biosynthesis and shows antifertility effects. Androsta-1,4,6-triene-3,17-dione induces impairment of spatial memory[1][2].
In Vivo	Androsta-1,4,6-triene-3,17-dione (25-100 mg/kg; s.c.) prevents the normal rise in ovarian estradiol concentrations[2].Androsta-1,4,6-triene-3,17-dione may act in vivo to inhibit fertility by inhibition of estrogen biosynthesis [1]. Animal Model:
Name	Androsta-1,4,6-triene-3,17-dione
CAS	633-35-2
Formula	C19H22O2
Molar Mass	282.38
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Covey DF, et al. Enzyme-generated intermediates derived from 4-androstene-3,6,17-trione and 1,4,6-androstatriene-3,17-dione cause a time-dependent decrease in human placental aromatase activity. Endocrinology. 1981 Apr;108(4):1597-9. [2]. Brodie AM, et al. Antifertility effects of an aromatase inhibitor, 1,4,6-androstatriene-3, 17-dione. Endocrinology. 1979 Jan;104(1):118-21.

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