| Bioactivity | Amyloid 17-42 (Aβ(17-42)) is a major constituent of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid in Down's syndrome, derived by alpha- and gamma-secretase cleavage of the amyloid precursor protein (APP). Amyloid 17-42 can induce neuronal apoptosis via a Fas-like/caspase-8 activation pathway[1]. |
| Invitro | Amyloid 17-42 (20 μM; 48 h) leads to apoptosis in SH-SY5Y and IMR-32 cells[1]. Amyloid 17-42 (20 μM; 48 h, 72 h) activates caspase-8 and caspase-3, induced poly(ADP-ribose) polymerase cleavage[1]. Amyloid 17-42 (20 μM) moderately activates c-Jun N-terminal kinase (JNK)[1].Amyloid 17-42 induces neuronal apoptosis via a Fas-like/caspase-8 activation pathway[1]. Cell Cytotoxicity Assay[1] Cell Line: |
| Name | Amyloid 17-42 |
| CAS | 155178-13-5 |
| Shortening | LVFFAEDVGSNKGAIIGLMVGGVVIA |
| Formula | C119H194N28O33S |
| Molar Mass | 2577.05 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Amyloid 17-42
CAS: 155178-13-5 F: C119H194N28O33S W: 2577.05
Amyloid 17-42 (Aβ(17-42)) is a major constituent of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid i
Data collection：peptidedb@qq.com
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